Endocrine Abstracts

To elucidate the functional role of IGFBP-2 for in vivo skeletal muscle growth and function, skeletal muscle cellularity and metabolism as well as body growth and composition have been studied in a transgenic mouse model overexpressing IGFBP-2. Postnatal growth rate of transgenic mice (n=20) was clearly reduced from day 21 of age by 6–8% (P<0.05) compared with non-transgenic controls (n=37). At the final day of live (day 72 of age) body pro...